Chaperone-mediated autophagy in protein quality control
نویسندگان
چکیده
منابع مشابه
Chaperone-mediated autophagy substrate proteins in cancer
All intracellular proteins undergo continuous synthesis and degradation. Chaperone-mediated autophagy (CMA) is necessary to maintain cellular homeostasis through turnover of cytosolic proteins (substrate proteins). This degradation involves a series of substrate proteins including both cancer promoters and suppressors. Since activating or inhibiting CMA pathway to treat cancer is still debated,...
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www.sciencemag.org (this information is current as of January 22, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/323/5910/124 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/323/5910/124/DC1 can be foun...
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The folding of most newly synthesized proteins in the cell requires the interaction of a variety of protein cofactors known as molecular chaperones. These molecules recognize and bind to nascent polypeptide chains and partially folded intermediates of proteins, preventing their aggregation and misfolding. There are several families of chaperones; those most involved in protein folding are the 4...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2011
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2010.10.009